Product Datasheet  
MDM2 Antibody  
Catalog Number: 48314  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q00987
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Amino acids 154-167 of MDM2 of human origin.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000
    IHC: 1:50-1:500

    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  • other_names：  
  • ACTFS antibody
    Double minute 2 protein antibody
    E3 ubiquitin-protein ligase Mdm2 antibody
    Hdm 2 antibody
    Hdm2 antibody
    HDMX antibody
    MDM 2 antibody
    MDM2 antibody
    MDM2 oncogene E3 ubiquitin protein ligase antibody
    Mdm2 p53 E3 ubiquitin protein ligase homolog antibody
    Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody
    MDM2_HUMAN antibody
    MDM2BP antibody
    Mouse Double Minute 2 antibody
    MTBP antibody
    Murine Double Minute Chromosome 2 antibody
    Oncoprotein Mdm2 antibody
    p53 Binding Protein Mdm2 antibody
    p53-binding protein Mdm2 antibody
    Ubiquitin protein ligase E3 Mdm2 antibody
    Ubiquitin protein ligase E3 Mdm2 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, IHC(P)
  • Background：  
  • p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. These findings argue that MDM2 overexpression represents at least one mechanism by which p53 function can be abrogated during tumorigenesis.



 
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