Product Datasheet  
HER4 / ErbB4 Antibody  
Catalog Number: 48301  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q15303
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Amino acids 1280-1308 at C-terminus of ErbB-4 of human origin.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000
    IHC: 1:50-500

    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
    FC: 1 μg per 1 x 106 cells
  • other_names：  
  • 4ICD antibody
    ALS19 antibody
    Avian erythroblastic leukemia viral oncogene homolog 4 antibody
    Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody
    E4ICD antibody
    EC 2.7.10.1 antibody
    Erbb4 antibody
    ERBB4 intracellular domain antibody
    ERBB4_HUMAN antibody
    HER 4 antibody
    HER4 antibody
    human epidermal growth factor receptor 4 antibody
    Mer4 antibody
    MGC138404 antibody
    Oncogene ERBB4 antibody
    p180erbB4 antibody
    Proto-oncogene-like protein c-ErbB-4 antibody
    Receptor protein tyrosine kinase erbB 4 precursor antibody
    Receptor tyrosine protein kinase erbB 4 antibody
    s80HER4 antibody
    Tyrosine kinase type cell surface receptor HER4 antibody
    Tyrosine kinase-type cell surface receptor HER4 antibody
    v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody
    v erb a erythroblastic leukemia viral oncogene homolog 4 antibody
    v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody
    V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody
    Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody
    Verba erythroblastic leukemia viral oncogene homolog 4 antibody
    VERBB2 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, IHC(P), FCM
  • Background：  
  • The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.



 
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