Product Datasheet
Granzyme B Antibody
Catalog Number: 48298
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.：
- Swiss-Prot#:P10144
- Form of Antibody：
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen：
- Amino acids 1-247 representing full length granzyme B of human origin.
- appl_detail：
- WB: 1:100-1:1,000
IHC: 1:50-500
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
- other_names：
- C11 antibody Cathepsin G like 1 antibody Cathepsin G-like 1 antibody CCPI antibody CGL 1 antibody CGL1 antibody CSP B antibody CSPB antibody CTLA-1 antibody CTLA1 antibody CTSGL1 antibody Cytotoxic serine protease B antibody Cytotoxic T lymphocyte associated serine esterase 1 antibody Cytotoxic T lymphocyte proteinase 2 antibody Cytotoxic T-lymphocyte proteinase 2 antibody Fragmentin 2 antibody Fragmentin-2 antibody GRAB_HUMAN antibody Granzyme 2 antibody Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody Granzyme B antibody Granzyme-2 antibody GranzymeB antibody GRB antibody Gzmb antibody Hlp antibody Human lymphocyte protein antibody Lymphocyte protease antibody Protease, serine, B antibody SECT antibody T cell serine protease 1-3E antibody T-cell serine protease 1-3E antibody
- Purification：
- ProA affinity purified
- Applications：
- WB, IP, IF, IHC(P)
- Background：
- Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degranulation. In activated CTLs, granzyme A and granzyme B are processed and activated by cathepsin C, and they then function to induce apoptosis by two distinct pathways. Granzyme B proteolytically cleaves and activates members of the caspase family of cysteine proteases, including caspase-3, caspase-6, caspase-7 and caspase-9. When cleaved, these caspases assemble into active holoenzymes that then mediate apoptosis through a defined proteolytic cascade involving nuclear lamins and PARP (poly ADP ribose polymerase). Granzyme A mediates the activation of apoptosis by inducing single-strand DNA breaks, membrane perturbation and nuclear condensations in an alternative pathway that is independent from caspase activation or the caspase proteolytic cascade.
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