Product Datasheet  
FOXM1 Antibody  
Catalog Number: 48295  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q08050
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000


    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  • other_names：  
  • FKHL16 antibody
    Forkhead box M1 antibody
    Forkhead box protein M1 antibody
    forkhead like 16 antibody
    Forkhead-related protein FKHL16 antibody
    FOX M1 antibody
    Foxm1 antibody
    FOXM1_HUMAN antibody
    FOXM1B antibody
    Hepatocyte nuclear factor 3 forkhead homolog 11 antibody
    HFH-11 antibody
    HFH11 antibody
    HNF-3/fork-head homolog 11 antibody
    HNF3 antibody
    INS1 antibody
    M phase phosphoprotein 2 antibody
    M-phase phosphoprotein 2 antibody
    MPHOSPH2 antibody
    MPM-2 reactive phosphoprotein 2 antibody
    MPP2 antibody
    PIG29 antibody
    TGT3 antibody
    Transcription factor Trident antibody
    Trident antibody
    WIN antibody
    Winged-helix factor from INS-1 cells antibody
    Winged-helix factor from INS1 cells antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF
  • Background：  
  • The Fox family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. FOXM1, also known as FKHL16, MPP2 or Trident, is primarily expressed in proliferating cells. The gene encoding human FOXM1 maps to chromosome 12p13. The transcription element that restricts FOXM1 expression to proliferating cells is located 300 bp upstream of the start codon. FOXM1 is most abundant in thymus, testis, small intestine and colon. Alternative splicing generates FOXM1A and FOXM1B isoforms that contain PEST regions involved in rapid protein degradation. A decrease in FOXM1 expression is associated with age-related defects in cellular proliferation. Conversely, an increase in FOXM1B expression in the livers of older transgenic mice restore hepatocyte DNA replication rates to the higher rate present in young livers. FOXM1B activates the transcription of cyclin B1, cyclin D1 and Cdc25B.



 
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