Product Datasheet  
FAK (Phospho-Ser 722) Antibody  
Catalog Number: 13327  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q05397
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000
    IHC: 1:50-1:500

    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  • other_names：  
  • FADK 1 antibody
    FADK antibody
    FAK related non kinase polypeptide antibody
    FAK1 antibody
    FAK1_HUMAN antibody
    Focal adhesion kinase 1 antibody
    Focal adhesion Kinase antibody
    Focal adhesion kinase isoform FAK Del33 antibody
    Focal adhesion kinase related nonkinase antibody
    FRNK antibody
    p125FAK antibody
    pp125FAK antibody
    PPP1R71 antibody
    Protein phosphatase 1 regulatory subunit 71 antibody
    Protein tyrosine kinase 2 antibody
    Protein-tyrosine kinase 2 antibody
    Ptk2 antibody
    PTK2 protein tyrosine kinase 2 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, IHC(P)
  • Background：  
  • Activation of integrins in the extracellular matrix (ECM) of eukaryotic cells promotes the formation of membrane adhesion complexes, known as focal adhesions, which can include cytoskeletal proteins and protein tyrosine kinases, such as focal adhesion kinase (FAK). Phosphorylation events occurring within focal adhesions influence numerous processes that include mitogenic signaling, cell survival and cell motility. FAK is a non-receptor tyrosine kinase that is ubiquitously expressed and highly conserved between species. FAK is recruited by integrin clusters and variably phosphorylated depending on the effector molecules present in the focal adhesion. Phospho-rylation of FAK Tyr 397 decreases during serum starvation, contact inhibition and cell cycle arrest, all conditions under which activating FAK Tyr 407 phosphorylation increases.



 
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