Product Datasheet
CD141 Antibody
Catalog Number: 48281
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:P07204
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- appl_detail:
- WB: 1:500-1:1000
IHC: 1:50-500
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
FC: 1 μg per 1 x 106 cells
- other_names:
- AHUS 6 antibody AHUS6 antibody BDCA 3 antibody BDCA3 antibody CD 141 antibody CD141 antibody CD141 antigen antibody Fetomodulin antibody Thbd antibody THPH12 antibody THRM antibody Thrombomodulin antibody TM antibody TRBM_HUMAN antibody
- Purification:
- ProA affinity purified
- Applications:
- WB, IP, IHC, FCM
- Background:
- Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.
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