Product Datasheet  
CD11c / ITGAX Antibody  
Catalog Number: 48280  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P20702
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,0000
    IHC: 1:50-500

    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  • other_names：  
  • 95 alpha chain antibody
    95 antibody
    CD 11c antibody
    CD11 antigen like family member C antibody
    CD11 antigen-like family member C antibody
    CD11c antibody
    CD11c antigen antibody
    Complement component 3 receptor 4 subunit antibody
    CR4 antibody
    Integrin alpha X antibody
    Integrin alpha X chain antibody
    Integrin alpha-X antibody
    Integrin aX antibody
    Integrin subunit alpha X antibody
    integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody
    integrin, alpha X (complement component 3 receptor 4 subunit antibody
    ITAX_HUMAN antibody
    ITGAX antibody
    LEU M5 alpha subunit antibody
    Leu M5 antibody
    Leukocyte adhesion glycoprotein p150 95 alpha chain antibody
    Leukocyte adhesion glycoprotein p150 antibody
    Leukocyte adhesion receptor p150 95 antibody
    Leukocyte adhesion receptor p150 antibody
    Leukocyte surface antigen p150 95 alpha subunit antibody
    Leukocyte surface antigen p150 alpha subunit antibody
    Myeloid membrane antigen alpha subunit antibody
    p150 95 integrin alpha chain antibody
    p150 antibody
    p150/95 antibody
    SLEB6 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, IHC(P)
  • Background：  
  • Integrin ?X (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with 2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin ?X/2 shares similar properties of the ?M/2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin ?X is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin ?X include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin ?X is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.



 
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