Product Datasheet  
CaMKII (Phospho-Thr 286) Antibody  
Catalog Number: 13322  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9UQM7
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Rt
  • appl_detail：  
  • WB: 1:100-1:1,000
    IHC: 1:50-1:500

    IP: 1-2 μg per 100-500 μg of total protein (1ml of cell lysate)
  • other_names：  
  • Calcium/calmodulin dependent protein kinase II alpha antibody
    Calcium/calmodulin dependent protein kinase II beta antibody
    Calcium/calmodulin dependent protein kinase II delta antibody
    Calcium/calmodulin dependent protein kinase II gamma antibody
    Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody
    CaM kinase II alpha antibody
    CaM kinase II antibody
    CaM kinase II beta antibody
    CaM kinase II delta antibody
    CaM kinase II gamma antibody
    CaM kinase II subunit alpha antibody
    CaMK-II subunit alpha antibody
    CAMK2 antibody
    Camk2a antibody
    CAMK2B antibody
    CAMK2D antibody
    CAMK2G antibody
    CAMKA antibody
    KCC2A_HUMAN antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF
  • Background：  
  • The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/ threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated α, β,γandδ, which may or may not be coexpressed in the same tissue types. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.



 
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