Product Datasheet  
ALAS2 Antibody  
Catalog Number: 48271  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P22557
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000
    IHC: 1:50-500

    IP: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate)
  • other_names：  
  • 5 @aminolevulinate synthase erythroid specific antibody
    5 aminolevulinate synthase 2 antibody
    5 aminolevulinate synthase 5 aminolevulinate synthase 2 antibody
    5 aminolevulinate synthase erythroid specific mitochondrial antibody
    5 aminolevulinic acid synthase 2 antibody
    5 aminolevulinic acid synthase antibody
    5-aminolevulinate synthase antibody
    5-aminolevulinic acid synthase 2 antibody
    Alas 2 antibody
    ALAS antibody
    ALAS E antibody
    ALAS, erythroid antibody
    ALAS-E antibody
    Alas2 antibody
    ALASE antibody
    Aminolevulinate delta synthase 2 antibody
    Aminolevulinic acid synthase 2, erythroid antibody
    ANH1 antibody
    ASB antibody
    Delta ALA synthase 2 antibody
    Delta ALA synthetase antibody
    Delta aminolevulinate synthase 2 antibody
    Delta aminolevulinate synthase antibody
    Delta-ALA synthase 2 antibody
    Delta-aminolevulinate synthase 2 antibody
    Erythroid specific ALAS antibody
    erythroid-specific antibody
    FLJ93603 antibody
    HEM0_HUMAN antibody
    mitochondrial antibody
    OTTHUMP00000023388 antibody
    OTTHUMP00000023389 antibody
    OTTMUSP00000020679 antibody
    RP23-338A17.1 antibody
    SIDBA1 antibody
    XLDPP antibody
    XLEPP antibody
    XLSA antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, IHC(P)
  • Background：  
  • 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.



 
© Signalway Biotechnology All Rights Reserved.