Product Datasheet  
GRP78 BiP Antibody  
Catalog Number: 48115  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P11021
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:5,000-1:10,000

    ICC: 1:200

  • other_names：  
  • 78 kDa glucose regulated protein antibody
    78 kDa glucose-regulated protein antibody
    AL022860 antibody
    AU019543 antibody
    BIP antibody
    D2Wsu141e antibody
    D2Wsu17e antibody
    Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody
    Endoplasmic reticulum lumenal Ca2+ binding protein grp78 antibody
    Epididymis secretory sperm binding protein Li 89n antibody
    FLJ26106 antibody
    Glucose Regulated Protein 78kDa antibody
    GRP 78 antibody
    GRP-78 antibody
    GRP78 antibody
    GRP78_HUMAN antibody
    Heat shock 70 kDa protein 5 antibody
    Heat Shock 70kDa Protein 5 antibody
    Heat shock protein family A (Hsp70) member 5 antibody
    HEL S 89n antibody
    Hsce70 antibody
    HSPA 5 antibody
    HSPA5 antibody
    Immunoglobulin Heavy Chain Binding Protein antibody
    Immunoglobulin heavy chain-binding protein antibody
    mBiP antibody
    MIF2 antibody
    Sez7 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC
  • Background：  
  • Binding immunoglobulin protein (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. Like many stress and heat shock proteins, BiP/GRP78 has potent immunological activity when released from the internal environment of the cell into the extracelluar space.specifically, it feeds anti-inflammatory and pro-resolutory signals into immune networks, thus helping to resolve inflammation.



 
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