Product Datasheet  
EEA1-Early Endosome Marker Antibody  
Catalog Number: 48112  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q15075
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu,Ms,Rt
  • appl_detail：  
  • WB: 1:2,000-1:5,000

    ICC: 1:100

  • other_names：  
  • Early endosome antigen 1 antibody
    Early endosome antigen 1, 162kD antibody
    Early endosome associated protein antibody
    EEA 1 antibody
    EEA1 antibody
    EEA1_HUMAN antibody
    Endosome associated protein p162 antibody
    Endosome-associated protein p162 antibody
    MST105 antibody
    MSTP105 antibody
    ZFYVE2 antibody
    Zinc finger FYVE domain containing protein 2 antibody
    Zinc finger FYVE domain-containing protein 2 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC
  • Background：  
  • EEA1 localizes exclusively to early endosomes?and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate?through its C-terminalFYVE domain?and forms a homodimer?through a?coiled coil. EEA1 acts as a tethering molecule that couples vesicle docking with SNAREs such as?N-ethylmaleimide sensitive fusion protein, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo. Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the vacuole.Mycobacterium tuberculosis?is known to inhibit the recruitment of EEA1 to the phagosomal membrane through CamKII. Legionella pneumophila?also prevents EEA1 recruitment through a currently unknown mechanism.[5] Interestingly, the related pathogen Legionella longbeachae?recruits EEA1 and appears to replicate within a modified early endosome.



 
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