Product Datasheet  
CK16 Mouse Monoclonal Antibody  
Catalog Number: 38011  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P08779
  • Form of Antibody：  
  • Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • IHC dilution: 1:200

    IF dilution:1:50-200
  • other_names：  
  • CK-16; CK16; cytokeratin 16; Cytokeratin-16; FNEPPK
  • Purification：  
  • Affinity purification using immunogen.
  • Specificity：  
  • The CK16 Mouse Monoclonal antibody detects endogenous CK16 proteins.
  • Applications：  
  • IHC,IF
  • Background：  
  • Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.



 
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