Product Datasheet  
ULBP1 Antibody  
Catalog Number: 40399  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9BZM6
    Gene Accssion:NP_079494
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide of human UL16 binding protein 1
  • reactivity：  
  • Hu
  • appl_detail：  
  • Immunohistochemistry: 1:100-1:200
  • other_names：  
  • RAET1I
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total ULBP1 protein.
  • Applications：  
  • IHC
  • Background：  
  • Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.



 
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