Product Datasheet
STARD5 Antibody
Catalog Number: 40375
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:Q9NSY2
Gene Accssion:NP_871629
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to residues near the N terminal of human StAR-related lipid transfer (START) domain containing 5
- appl_detail:
- Western blotting: 1:500-1:2000
Immunohistochemistry:1:40-1:150
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total STARD5 protein.
- Background:
- Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake.
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