Product Datasheet
VPS26A Antibody
Catalog Number: 40295
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:O75436
Gene Accssion:NP_004887
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide of human vacuolar protein sorting 26 homolog A (S. pombe)
- appl_detail:
- Western blotting: 1:500-1:2000
Immunohistochemistry:1:30-1:150
- other_names:
- HB58; PEP8A; VPS26; Hbeta58
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total VPS26A protein.
- Background:
- This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
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