Product Datasheet
KCNK3 Antibody
Catalog Number: 40236
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:O35111
Gene Accssion:NP_034738
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to residues near the C terminal of human potassium channel, subfamily K, member 3
- appl_detail:
- Western blotting: 1:500-1:2000
Immunohistochemistry:1:10-1:50
- other_names:
- TASK; Task-1; cTBAK-1
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total KCNK3 protein.
- Background:
- TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54% identity with TASK-1, but less than 30% identity with TASK-2 and other tandem pore K+ channels.
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