Product Datasheet
SORT1 Antibody
Catalog Number: 40218
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:Q99523
Gene Accssion:NP_002950
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to residues near the C terminal of human sortilin 1
- appl_detail:
- Western blotting: 1:500-1:2000
Immunohistochemistry:1:35-1:150
- other_names:
- NT3; Gp95; LDLCQ6
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total SORT1 protein.
- Background:
- This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail.?
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