Product Datasheet
RORA Antibody
Catalog Number: 40212
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:P35398
Gene Accssion:NP_002934
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to residues near the N terminal of human RAR-related orphan receptor A
- appl_detail:
- Western blotting: 1:500-1:2000
- other_names:
- ROR1; ROR2; ROR3; RZRA; NR1F1; RZR-ALPHA
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total RORA protein.
- Background:
- The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm.
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