Product Datasheet
THAP4 Antibody
Catalog Number: 40142
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:Q8WY91
Gene Accssion:BC000247
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to residues near the C terminal of human THAP domain containing 4
- appl_detail:
-
Immunohistochemistry: 1:100-1:200
- other_names:
- PP238; CGI-36
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total THAP4 protein.
- Background:
- Human THAP4 is a 577 residue protein of unknown function that is proposed to bind DNA in a sequence specific manner similar to THAP1 and has been found to be upregulated in response to heat shock.THAP4 is expressed in a relatively uniform manner in a broad range of tissues and appears to be upregulated in lymphoma cells and highly expressed in heart cells13. The C-terminal domain of THAP4 (residues 415-577), designated here as cTHAP4, is evolutionarily conserved and is observed in all know THAP4 orthologues. Several single domain proteins lacking a THAP domain are found in plants and bacteria, and show significant levels of homology to cTHAP4. It appears that cTHAP4 belongs to a large class of proteins that have yet to be fully functionally characterized.
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