Product Datasheet  
IRAK Monoclonal Antibody  
Catalog Number: 26040  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year.
  • Immunogen：  
  • Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • other_names：  
  • IRAK (1F12C1),IL-1-Receptor Associated Kinase
  • Purification：  
  • Immunoaffinity chromotography purified IgG
  • Specificity：  
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).



 
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