Product Datasheet  
MD-2 Monoclonal Antibody  
Catalog Number: 26027  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9Y6Y9
    Gene ID:23643
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year.
  • Immunogen：  
  • Raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • MD-2 (1A2E3): Lymphocyte antigen 96 precursor, ESOP-1
  • Purification：  
  • Immunoaffinity chromotography purified IgG
  • Specificity：  
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.



 
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