Product Datasheet
EDA2R Antibody
Catalog Number: 36434
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: Q9HAV5
NCBI Gene ID: 60401
Gene Accssion: BC034919
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to residues near the C terminal of human ectodysplasin A2 receptor
- appl_detail:
- Immunohistochemistry: 1:50-1:200
- other_names:
- XEDAR; EDAA2R; EDA-A2R; TNFRSF27
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total EDA2R protein.
- Background:
- EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.
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