Product Datasheet
KCNMA1 Antibody
Catalog Number: 36283
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: Q12791
NCBI Gene ID: 3778
Gene Accssion: BC062659
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to residues near the C terminal of human potassium large conductance calcium-activated channel, subfamily M, alpha member 1
- appl_detail:
- Immunohistochemistry: 1:25-1:100
- other_names:
- SLO; BKTM; SLO1; MaxiK; SAKCA; mSLO1; KCa1.1; SLO-ALPHA; bA205K10.1
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total KCNMA1 protein.
- Background:
- MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
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