Product Datasheet
BCAT1 Antibody
Catalog Number: 36276
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P54687
NCBI Gene ID: 586
Gene Accssion: NP_005495
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to a region derived from internal residues of human branched chain amino-acid transaminase 1, cytosolic
- appl_detail:
- Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100
- other_names:
- BCT1; PP18; BCATC; ECA39; MECA39; PNAS121
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total BCAT1 protein.
- Background:
- This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.
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