Product Datasheet
MAP4K2 Antibody
Catalog Number: 36189
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: Q12851
NCBI Gene ID: 5871
Gene Accssion: BC047865
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to residues near the C terminal of human mitogen-activated protein kinase kinase kinase kinase 2
- appl_detail:
- Western blotting: 1:1000-1:5000
- other_names:
- GCK; BL44; RAB8IP
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total MAP4K2 protein.
- Background:
- The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.?
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