Product Datasheet
LTA Antibody
Catalog Number: 35964
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P01374
NCBI Gene ID: 4049
Gene Accssion: BC034729
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to a region derived from internal residues of human lymphotoxin alpha (TNF superfamily, member 1)
- appl_detail:
- Immunohistochemistry: 1:50-1:200
- other_names:
- LT; TNFB; TNFSF1
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total LTA protein.
- Background:
- The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.
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