Product Datasheet  
b-Catenin(Phospho-Thr41/Ser45) Antibody  
Catalog Number: 11116  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P35222
    NCBI Protein: NP_001091679.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around phosphorylation site of threonine 41/serine 45 (A-T-T(p)-T-A-P-S(p)-L-S) derived from Human b-Catenin.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 92kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • CTNNB1; CATNB; CTNB1; CTNNB;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Specificity：  
  • The antibody detects endogenous level of b-Catenin only when phosphorylated at threonine 41/serine 45.
  • Applications：  
  • WB
  • Background：  

  • Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

    Provost E, et al. (2003)J Biol Chem 22; 278(34): 31781-9.
    Sakanaka C , et al. (2003)J Biochem (Tokyo); 132(5): 697-703.
    Amit S, et al. (2002) Genes Dev; 16(9): 1066-76.
    Liu C, et al. (2002) Cell; 108(6): 837-47.
    Provost E, et al. (2005) Oncogene; 24(16): 2667-76.




 
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