Product Datasheet  
RIP Antibody  
Catalog Number: 35482  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q13546;
    NCBI Gene#:8737
  • Form of Antibody：  
  • Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fragment corresponding to a region within amino acids 371 and 635 of RIP.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500-1:3000
  • other_names：  
  • FLJ39204 antibody; RIP antibody; RIP1 antibody; RIPK1 antibody; cell death protein RIP antibody; receptor-interacting serine/threonine-protein kinase 1 antibody; serine/threonine-protein kinase RIP antibody; receptor-interacting protein 1 antibody; RIP-1
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total RIP protein.
  • Applications：  
  • WB
  • Background：  
  • Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.



 
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