Product Datasheet  
NSF Antibody  
Catalog Number: 35470  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P46459;
    NCBI Gene#:4905
  • Form of Antibody：  
  • Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fragment corresponding to a region within amino acids 1 and 292 of NSF.
  • reactivity：  
  • Hu Rt Ms
  • appl_detail：  
  • Western blotting: 1:500-1:3000
  • other_names：  
  • SKD2 antibody; NSF antibody; vesicle-fusing ATPase antibody; N-ethylmaleimide-sensitive factor-like protein antibody; vesicular-fusion protein NSF antibody; NEM-sensitive fusion protein antibody; N-ethylmaleimide-sensitive fusion protein antibody; N-ethyl
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total NSF protein.
  • Applications：  
  • WB
  • Background：  
  • NSF required for intracellular membrane fusion and vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Functions as a SNAP receptor (SNARE) chaperone which binds, through soluble NSF attachment proteins (SNAPs), to SNARE complexes and utilizes the energy of ATP hydrolysis to disassemble them thus facilitating SNARE recycling. While this is a major function of NSF, it does seem to interact with other proteins, such as the AMPA receptor subunit, GluR2, and beta2-AR and is thought to affect their trafficking patterns.



 
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