Product Datasheet  
TLR4 Antibody  
Catalog Number: 35463  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O00206;
    NCBI Gene#:7099
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • A synthesized peptide derived from human TLR4
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500-1:2000
    Immunofluorescence: 1:50-1:200

  • other_names：  
  • ARMD10 antibody; CD284 antibody; TOLL antibody; hToll antibody; TLR4 antibody; homolog of Drosophila toll antibody; toll-like receptor 4 antibody
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total TLR4 protein.
  • Applications：  
  • WB IHC
  • Background：  

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq]




 
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