Product Datasheet  
GRK2 Antibody  
Catalog Number: 35449  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P25098;
    NCBI Gene#:156
  • Form of Antibody：  
  • Rabbit IgG in 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fragment corresponding to a region within amino acids 322 and 689 of GRK2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500-1:3000
  • other_names：  
  • BARK1 antibody; BETA-ARK1 antibody; FLJ16718 antibody; GRK2 antibody; ADRBK1 antibody; G-protein coupled receptor kinase 2 antibody; beta-ARK-1 antibody; beta-adrenergic receptor kinase 1 antibody; "adrenergic; beta; receptor kinase 1 antibody"
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total GRK2 protein.
  • Applications：  
  • WB
  • Background：  
  • The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]



 
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