Product Datasheet  
FGFR1 Antibody  
Catalog Number: 35445  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P11362;
    NCBI Gene#:2260
  • Form of Antibody：  
  • Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fragment contain a sequence corresponding to a region within amino acids 422 and 789 of FGFR1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:1000-1:10000
  • other_names：  
  • BFGFR antibody; CD331 antibody; CEK antibody; FGFBR antibody; FLG antibody; FLJ99988 antibody; FLT2 antibody; HBGFR antibody; KAL2 antibody; N-SAM antibody; OGD antibody; FGFR1 antibody; heparin-binding growth factor receptor antibody; hydroxyaryl-protein
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total FGFR1 protein.
  • Applications：  
  • WB
  • Background：  
  • The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]



 
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