Product Datasheet  
NRG1 Antibody  
Catalog Number: 35356  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q02297;
    NCBI Gene#:3084
  • Form of Antibody：  
  • Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fragment contain a sequence corresponding to a region within amino acids 1 and 211 of NRG1.
  • reactivity：  
  • Ms
  • appl_detail：  
  • Western blotting: 1:500-1:3000
  • other_names：  
  • ARIA antibody; GGF antibody; GGF2 antibody; HGL antibody; HRG antibody; HRG1 antibody; HRGA antibody; MST131 antibody; NDF antibody; SMDF antibody; NRG1 antibody; MSTP131 antibody; glial growth factor antibody; sensory and motor neuron derived factor anti
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total NRG1 protein.
  • Applications：  
  • WB
  • Background：  
  • Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. [provided by RefSeq]



 
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