Product Datasheet  
MDM2 Antibody  
Catalog Number: 35346  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q00987;
    NCBI Gene#:4193
  • Form of Antibody：  
  • Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide contain a sequence corresponding to a region within amino acids 98 and 161 of MDM2.
  • reactivity：  
  • Ms
  • appl_detail：  
  • Western blotting: 1:500-1:3000
  • other_names：  
  • HDMX antibody; MGC5370 antibody; MGC71221 antibody; hdm2 antibody; MDM2 antibody; Mdm2; transformed 3T3 cell double minute 2; p53 binding protein antibody; MDM2 variant FB30 antibody; double minute 2; human homolog of; p53-binding protein antibody; MDM2 v
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total MDM2 protein.
  • Applications：  
  • WB
  • Background：  
  • This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq]



 
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