Product Datasheet  
p21 Antibody  
Catalog Number: 35343  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P38936;
    NCBI Gene#:1026
  • Form of Antibody：  
  • Rabbit IgG in 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fragment corresponding to a region within amino acids 1 and 164 of p21.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500-1:3000
    Immunofluorescence: 1:100-1:1000
  • other_names：  
  • CAP20 antibody; CDKN1 antibody; CIP1 antibody; MDA-6 antibody; P21 antibody; SDI1 antibody; WAF1 antibody; p21CIP1 antibody; CDKN1A antibody; cyclin-dependent kinase inhibitor 1 antibody; melanoma differentiation associated protein 6 antibody; wild-type p
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total p21 protein.
  • Applications：  
  • IF WB
  • Background：  
  • This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]



 
© Signalway Biotechnology All Rights Reserved.