Product Datasheet  
Rad17 Antibody  
Catalog Number: 35336  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O75943;
    NCBI Gene#:5884
  • Form of Antibody：  
  • Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fragment corresponding to a region within amino acids 389 and 681 of Rad17.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500-1:3000
  • other_names：  
  • CCYC antibody; FLJ41520 antibody; HRAD17 antibody; R24L antibody; RAD17SP antibody; RAD24 antibody; RAD17 antibody; cell cycle checkpoint protein (RAD17) antibody; cell cycle checkpoint protein RAD17 antibody; RAD1 homolog antibody; RF-C activator 1 homol
  • Purification：  
  • Antibodies were purified by antigen-affinity chromatography.
  • Specificity：  
  • The antibody detects endogenous levels of total Rad17 protein.
  • Applications：  
  • WB
  • Background：  
  • The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq]



 
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