Product Datasheet
PTPRZ1 Antibody
Catalog Number: 34977
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot: P23471
NCBI Gene ID: 5803
- Form of Antibody:
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from N-terminal of human PTPRZ1.
- appl_detail:
- Western blotting: 1:500~1:3000
- other_names:
- R-PTP-zeta; Protein-tyrosine phosphatase receptor type Z polypeptide 1;
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Specificity:
- The antibody detects endogenous levels of total PTPRZ1 protein.
- Background:
- Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades By similarity.
Krueger N.X., Proc. Natl. Acad. Sci. U.S.A. 89:7417-7421(1992).
Levy J.B., J. Biol. Chem. 268:10573-10581(1993).
Hillier L.W., Nature 424:157-164(2003).
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