Product Datasheet  
PTGR1 Antibody  
Catalog Number: 34841  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q14914
    NCBI Gene ID: 22949
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human PTGR1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Prostaglandin reductase 1; PRG-1; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; EC=1.3.1.74; 15-oxoprostaglandin 13-reductase
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total PTGR1 protein.
  • Applications：  
  • WB
  • Background：  
  • Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha By similarity. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.

    Humphray S.J., Nature 429:369-374(2004).
    The MGC Project Team; Genome Res. 14:2121-2127(2004).
    Yokomizo T., J. Biol. Chem. 271:2844-2850(1996)



 
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