Product Datasheet  
MLF1 Antibody  
Catalog Number: 34814  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P58340
    NCBI Gene ID: 4291
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human MLF1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total MLF1 protein.
  • Applications：  
  • WB
  • Background：  
  • Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

    Yoneda-Kato N., Oncogene 12:265-275(1996) [PubMed: 8570204].
    Hanissian S.H., Oncogene 23:3700-3707(2004) [PubMed: 15116101].
    Yoneda-Kato N., EMBO J. 24:1739-1749(2005) [PubMed: 15861129].



 
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