Product Datasheet  
GADD45GIP1 Antibody  
Catalog Number: 34708  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q8TAE8
    NCBI Gene ID: 90480
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human GADD45GIP1.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Growth arrest and DNA-damage-inducible proteins-interacting protein 1; CR6-interacting factor 1; CRIF1; CKII beta-associating protein; Papillomavirus L2-interacting nuclear protein 1
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total GADD45GIP1 protein.
  • Applications：  
  • IHC
  • Background：  
  • Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

    Goernemann J., Virology 303:69-78(2002).
    Chung H.K., J. Biol. Chem. 278:28079-28088(2003).
    The MGC Project Team, Genome Res. 14:2121-2127(2004).



 
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