Product Datasheet  
DHRS2 Antibody  
Catalog Number: 34643  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q13268
    NCBI Gene ID: 10202
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human DHRS2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • dehydrogenase/reductase (SDR family) member 2; dehydrogenase/reductase SDR family member 2; HEP27; protein D; SDR25C1
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total DHRS2 protein.
  • Applications：  
  • WB
  • Background：  
  • Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.

    Gabrielli F., Eur. J. Biochem. 232:473-477(1995).
    Pellegrini S., Biochim. Biophys. Acta 1574:215-222(2002).
    Suzuki Y., Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.



 
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