Product Datasheet  
COMT Antibody  
Catalog Number: 34554  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P21964
    NCBI Gene ID: 1312
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human COMT.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Catechol O-methyltransferase; membrane-bound form; catechol-O-methyltransferase; EC 2.1.1.6; MB-COMT
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total COMT protein.
  • Applications：  
  • WB
  • Background：  
  • Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

    Lundstroem K., DNA Cell Biol. 10:181-189(1991).
    Bertocci B., Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991).
    Tenhunen J., Eur. J. Biochem. 223:1049-1059(1994).



 
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