Product Datasheet  
PHLDA3 Antibody  
Catalog Number: 34295  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9Y5J5
    NCBI Gene ID: 23612
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human PHLDA3.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100

  • other_names：  
  • Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; PHLDA3; TIH1;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total PHLDA3 protein.
  • Applications：  
  • IHC
  • Background：  

  • p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

    Frank D., Mamm. Genome 10:1150-1159(1999).
    Ota T., Nat. Genet. 36:40-45(2004).
    The MGC Project Team, Genome Res. 14:2121-2127(2004).




 
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