Product Datasheet  
DCC Antibody  
Catalog Number: 34265  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P43146
    NCBI Gene ID: 1630
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human DCC.
  • reactivity：  
  • Hu
  • appl_detail：  


  • Immunofluorescence: 1:100~1:500
  • other_names：  
  • colorectal cancer suppressor; deleted in colorectal carcinoma; netrin receptor DCC; tumor suppressor protein DCC;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total DCC protein.
  • Applications：  
  • IF
  • Background：  
  • Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

    Hedrick L., Genes Dev. 8:1174-1183(1994).
    Cho K.R., Genomics 19:525-531(1994).
    Sjoeblom T., Science 314:268-274(2006).



 
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