Product Datasheet  
Cyclosome 1 Antibody  
Catalog Number: 34257  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9H1A4
    NCBI Gene ID: 64682
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human Cyclosome 1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  


  • Immunofluorescence: 1:100~1:500
  • other_names：  
  • ANAPC1; ANC1; Anaphase promoting complex subunit 1; Cyclosome subunit 1; Mitotic checkpoint regulator
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Cyclosome 1 protein.
  • Applications：  
  • IF
  • Background：  
  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

    Joergensen P.M., Gene 262:51-59(2001).
    Ota T., Nat. Genet. 36:40-45(2004).
    Kraft C., EMBO J. 22:6598-6609(2003).



 
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