Product Datasheet  
DBF4 Antibody  
Catalog Number: 34095  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UBU7
    NCBI Gene ID: 10926
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from N-terminal of human DBF4.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Protein DBF4 homolog A; Activator of S phase kinase; DBF4-type zinc finger-containing protein 1; Chiffon homolog A; DBF4
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total DBF4 protein.
  • Applications：  
  • WB
  • Background：  
  • Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.

    Kumagai H., Mol. Cell. Biol. 19:5083-5095(1999).
    Jiang W., EMBO J. 18:5703-5713(1999).
    Ota T., Nat. Genet. 36:40-45(2004).



 
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