Product Datasheet  
PARD3 Antibody  
Catalog Number: 33992  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q8TEW0
    NCBI Gene ID: 56288
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human PARD3.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000

    Immunofluorescence: 1:100~1:500
  • other_names：  
  • Partitioning-defective 3 homolog; PARD-3; PAR-3; Atypical PKC isotype-specific-interacting protein; ASIP
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total PARD3 protein.
  • Applications：  
  • WB IF
  • Background：  
  • Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions By similarity. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

    Joberty G., Nat. Cell Biol. 2:531-539(2000).
    Fang C.M., Cell Res. 11:223-229(2001).
    Kohjima M., Biochem. Biophys. Res. Commun. 299:641-646(2002).



 
© Signalway Biotechnology All Rights Reserved.