Product Datasheet  
KSR2 Antibody  
Catalog Number: 33940  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q6VAB6
    NCBI Gene ID: 283455
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human KSR2.
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • Western blotting: 1:500~1:3000

    Immunofluorescence: 1:100~1:500

  • other_names：  
  • hKSR2; Kinase suppressor of Ras 2; KSR2;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total KSR2 protein.
  • Applications：  
  • WB IF
  • Background：  

  • Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

    Ota T., Nat. Genet. 36:40-45(2004).
    Scherer S.E., Nature 440:346-351(2006).
    Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003).




 
© Signalway Biotechnology All Rights Reserved.