Product Datasheet  
WTAP Antibody  
Catalog Number: 33889  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q15007
    NCBI Gene ID: 9589
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from C-terminal of human WTAP.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500~1:3000

  • other_names：  
  • KIAA0105; Putative pre-mRNA splicing regulator female-lethal (2D) homolog; WT1-associated protein; Wilms' tumor 1-associating protein;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total WTAPv protein.
  • Applications：  
  • WB,IHC,IF/ICC,ELISA
  • Background：  

  • Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.

    Ortega A., J. Biol. Chem. 278:3040-3047(2003).
    Nagase T., DNA Res. 2:37-43(1995).
    Mungall A.J., Nature 425:805-811(2003).




 
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