Product Datasheet  
ELL Antibody  
Catalog Number: 33821  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P55199
    NCBI Gene ID: 8178
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human ELL.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • RNA polymerase II elongation factor ELL; RNA polymerase II elongation factor ELL; ELL; C19orf17;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total ELL protein.
  • Applications：  
  • WB
  • Background：  
  • Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.

    Thirman M.J., Proc. Natl. Acad. Sci. U.S.A. 91:12110-12114(1994).
    Simone F., Blood 98:201-209(2001).
    Kong S.E., Proc. Natl. Acad. Sci. U.S.A. 102:10094-10098(2005).



 
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